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|Title: ||Catalytic inhibition of topoisomerase II in Werner’s syndrome cell lines enhances chromosomal damage induced by X-rays in the G2 phase of cell cycle|
|Authors: ||Franchitto, Annapaola|
|Issue Date: ||2000|
|Publisher: ||Taylor and Francis|
|Citation: ||Franchitto, A. et al. 2000. Catalytic inhibition of topoisomerase II in Werner’s syndrome cell lines enhances chromosomal damage induced by X-rays in the G2 phase of cell cycle. "International Journal of Radiation Biology" 76(7): 913-922.|
|Abstract: ||PURPOSE: To investigate whether catalytic topoisomerase II activity by ICRF187, a compound that interferes with the catalytic cycle of topoisomerase II without causing DNA damage, could result in a modulation of X-ray-induced chromosomal damage in Werner's syndrome (WS) cell lines.
MATERIALS AND METHODS: Two WS (KO375, DJG) and one normal lymphoblastoid cell line (SNW646) were exposed to X-rays, post-treated with ICRF187 and harvested after various recovery times. Cell progression to mitosis |
|Description: ||L'articolo è disponibile sul sito dell'editore: http://www.taylorandfrancisgroup.com|
|Appears in Collections:||DABAC - Archivio della produzione scientifica|
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