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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1710

Title: Werner‘s syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle
Authors: Pichierri, Pietro
Franchitto, Annapaola
Mosesso, Pasquale
Palitti, Fabrizio
Keywords: Werner syndrome
DNA damage
DNA Replication
Issue Date: 2001
Publisher: American Society for Cell Biology
Citation: Pichierri, P. et al. 2001. Werner‘s syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle. "Molecular Biology of the Cell" 12(8): 2412-2421
Abstract: Werner's syndrome (WS) is a rare autosomal recessive disorder that arises as a consequence of mutations in a gene coding for a protein that is a member of RecQ family of DNA helicases, WRN. The cellular function of WRN is still unclear, but on the basis of the cellular phenotypes of WS and of RecQ yeast mutants, its possible role in controlling recombination and/or in maintenance of genomic integrity during S-phase has been envisaged. With the use of two drugs, camptothecin and hydroxyurea, whic
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Description: L'articolo é disponibile sul sito dell'editore: http://www.molbiolcell.org
URI: http://hdl.handle.net/2067/1710
ISSN: 1059-1524
Appears in Collections:DABAC - Archivio della produzione scientifica

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