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http://hdl.handle.net/2067/1662
Title: | Molecular modelling of co-receptor CD8αα and its complex with MHC class I and T-cell receptor in sea bream (Sparus aurata) | Authors: | Costantini, Susan Buonocore, Francesco Facchiano, Angelo M. |
Keywords: | Fish Immunology;Molecular Biology;Sparus aurata;Molecular modelling;Protein structure;CD8;T-cell receptor;MHC-I | Issue Date: | 2011 | Publisher: | Elsevier | Source: | Costantini, S., Buonocore, F., Facchiano, A.M. 2008. Molecular modelling of co-receptor CD8αα and its complex with MHC class I and T-cell receptor in sea bream (Sparus aurata). "Fish and Shellfish Immunology" 25(6): 782-790 | Abstract: | T-cells are the main actors of cell-mediated immune defence; they recognize and respond to peptide antigens associated with MHC class I and class II molecules. In this paper, we investigated by molecular modelling methods in the teleost sea bream (Sparus aurata) the interaction among the molecules of the tertiary complex CD8/MHC-I/TCR, which determines the T-cell-mediated immunological response to foreign molecules. First, we predicted the three-dimensional structure of CD8αα dimer and MHC-I, and, successively, we simulated the CD8αα/MHC-I complex. Finally, the 3D structure of the CD8/MHC-I/TCR complex was simulated in order to investigate the possible changes that can influence TCR signalling events. |
Description: | L'articolo è disponibile sul sito dell'editore http://www.sciencedirect.com/ |
URI: | http://hdl.handle.net/2067/1662 | ISSN: | 1050-4648 | DOI: | 10.1016/j.fsi.2008.03.020 |
Appears in Collections: | DISA - Archivio della produzione scientifica |
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yfsim_1145.pdf | 1.03 MB | Adobe PDF | View/Open |
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