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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1662

Title: Molecular modelling of co-receptor CD8αα and its complex with MHC class I and T-cell receptor in sea bream (Sparus aurata)
Authors: Costantini, Susan
Buonocore, Francesco
Facchiano, Angelo M.
Keywords: Fish Immunology
Molecular Biology
Sparus aurata
Molecular modelling
Protein structure
CD8
T-cell receptor
MHC-I
Issue Date: 2011
Publisher: Elsevier
Citation: Costantini, S., Buonocore, F., Facchiano, A.M. 2008. Molecular modelling of co-receptor CD8αα and its complex with MHC class I and T-cell receptor in sea bream (Sparus aurata). "Fish and Shellfish Immunology" 25(6): 782-790
Abstract: T-cells are the main actors of cell-mediated immune defence; they recognize and respond to peptide antigens associated with MHC class I and class II molecules. In this paper, we investigated by molecular modelling methods in the teleost sea bream (Sparus aurata) the interaction among the molecules of the tertiary complex CD8/MHC-I/TCR, which determines the T-cell-mediated immunological response to foreign molecules. First, we predicted the three-dimensional structure of CD8αα dimer and MHC-I, an
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Description: L'articolo è disponibile sul sito dell'editore http://www.sciencedirect.com/
DOI: 10.1016/j.fsi.2008.03.020
URI: http://hdl.handle.net/2067/1662
ISSN: 1050-4648
Appears in Collections:DISA - Archivio della produzione scientifica

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