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Please use this identifier to cite or link to this item:
http://hdl.handle.net/2067/1581
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| Title: | Synthesis of a novel ester of hydroxytyrosol and lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells |
| Authors: | Bernini, Roberta
Crisante, Fernanda
Merendino, Nicolò
Molinari, Romina
Soldatelli, Maria Chiara
Velotti, Francesca |
| Keywords: | Polyphenols
Antitumor
Colon cancer |
| Issue Date: | 2010 |
| Publisher: | Imprim Vert |
| Citation: | Bernini, R. et al. 2010 Synthesis of a novel ester of hydroxytyrosol and lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells. In: Ageorges, A. et al. (a cura di). Polyphenols Communications 2010. XXVth International Conference on Polyphenols (Montpellier, 24-27 August 2010). Montpellier, Imprim Vert, pp. 98-99 |
| Abstract: | A novel hydroxytyrosol-lipoic acid derivative has been synthesized. Key steps are an
esterification reaction between tyrosol and cJipoic acid derivatives and a regioselective aromatic
hydroxylation ofthe monohydroxylated ester performed by 2-iodoxybenzoic acid (IBX) followed by an
in situ reductionw ith sodium dithionite (Na2S2O4T).h e novel estere xhibited an antiproliferative effect on
the human colorectal adenocarcinoma HT-29 cell line signifrcantly more potent than its parent compounds. |
| URI: | http://hdl.handle.net/2067/1581 |
| ISBN: | 978-2-7388-1282-1 |
| Appears in Collections: | DECOS - Archivio della produzione scientifica
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