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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1578

Title: Granzyme B is expressed in urothelial carcinoma and promotes cancer cell invasion
Authors: D'Eliseo, Donatella
Pisu, Paola
Romano, Chiara
Tubaro, Andrea
De Nunzio, Cosimo
Morrone, Stefania
Santoni, Angela
Stoppacciaro, Antonella
Velotti, Francesca Romana
Keywords: Tumor invasion
Granzyme B
Urothelial carcinoma
Issue Date: 2010
Publisher: Wiley-Blackwell
Citation: D'Eliseo, D. et al. 2010. Granzyme B is expressed in urothelial carcinoma and promotes cancer cell invasion. "International Journal of Cancer" 127 (6): 1283-1294
Abstract: Granzyme B (GrB) is a serine proteinase known to be expressed by cytotoxic lymphocytes and to induce, in presence of perforin (Pf), apoptosis in target cells. Recently, GrB expression has been shown (often in absence of Pf) in non-lymphoid cells, but its function is not defined. In this study, we investigated GrB and Pf expression in bladder cancer cell lines and in urothelial carcinoma (UC) tissues by RT-PCR, Western blot, ELISA, immunofluorescence, and immunohistochemistry. We also assessed th
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Description: L'articolo è disponibile sul sito dell'editore http://onlinelibrary.wiley.com
DOI: 10.1002/ijc.25135
URI: http://hdl.handle.net/2067/1578
ISSN: 0020-7136
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