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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1577

Title: The use of filamentous bacteriophage fd to deliver MAGE-A10 or MAGE-A3 HLA-A2-restricted peptides and to induce strong antitumor CTL responses
Authors: Sartorius, Rossella
Pisu, Paola
D'Apice, Luciana
Pizzella, Luciano
Romano, Chiara
Cortese, Giancarlo
Giorgini, Angela
Santoni, Angela
De Berardinis, Piergiuseppe
Velotti, Francesca Romana
Keywords: Vaccine
Cytotoxic T lymphocytes
Tumor immunology
Bladder cancer
Issue Date: 2008
Publisher: American Association of Immunologists
Citation: Sartorius, R. et al. 2008. The use of filamentous bacteriophage fd to deliver MAGE-A10 or MAGE-A3 HLA-A2-restricted peptides and to induce strong antitumor CTL responses. "Journal of Immunology" 180 (6): 3719-3728
Abstract: Delivery of tumor-associated antigen (TAA)-derived peptides in a high immunogenic form represents one of the key issues for effective peptide-based cancer vaccine development. Here, we report the ability of non-pathogenic filamentous bacteriophage fd virions to deliver HLA-A2-restricted MAGE-A10254-262- or MAGE-A3271-279-derived peptides and elicit potent specific CTL responses in vitro and in vivo. Interestingly, human anti-MAGE-A3271-279-specific CTLs were able to kill human MAGE-A3+ tumor cel
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Description: L'articolo è disponibile sul sito dell'editore http://www.jimmunol.org
URI: http://hdl.handle.net/2067/1577
ISSN: 0022-1767
Appears in Collections:DECOS - Archivio della produzione scientifica

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