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http://hdl.handle.net/2067/1571
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| Title: | Synthesis of a novel ester of hydroxytyrosol and lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells |
| Authors: | Bernini, Roberta
Crisante, Fernanda
Merendino, Nicolò
Molinari, Romina
Soldatelli, Maria Chiara
Velotti, Francesca |
| Keywords: | Hydroxytyrosol
Lipoic acid
New ester
Antiproliferative effect
HT-29 cells |
| Issue Date: | 2010 |
| Publisher: | Imprim Vert |
| Citation: | Bernini, R. et al. 2010 Synthesis of a novel ester of hydroxytyrosol and lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells. In: Ageorges, A. et al. (a cura di). XXV Th International Conference on Polyphenols. Polyphenols Communications 2010. (Montpellier, France 24-27 August). 1: 98-99 |
| Abstract: | A novel hydroxytyrosol-lipoic acid derivative has been synthesized. Key steps are an esterification reaction between tyrosol and -lipoic acid derivatives and a regioselective aromatic hydroxylation of the monohydroxylated ester performed by 2-iodoxybenzoic acid (IBX) followed by an in situ reduction with sodium dithionite (Na2S2O4). The novel ester exhibited an antiproliferative effect on the human colorectal adenocarcinoma HT-29 cell line significantly more potent than its parent compounds |
| URI: | 978-2-7380-1282-1
http://hdl.handle.net/2067/1571 |
| Appears in Collections: | DABAC - Archivio della produzione scientifica
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