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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1571

Title: Synthesis of a novel ester of hydroxytyrosol and lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells
Authors: Bernini, Roberta
Crisante, Fernanda
Merendino, Nicolò
Molinari, Romina
Soldatelli, Maria Chiara
Velotti, Francesca Romana
Keywords: Hydroxytyrosol
Lipoic acid
New ester
Antiproliferative effect
HT-29 cells
Issue Date: 2010
Publisher: Imprim Vert
Citation: Bernini, R. et al. 2010 Synthesis of a novel ester of hydroxytyrosol and lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells. In: Ageorges, A. et al. (a cura di). XXV Th International Conference on Polyphenols. Polyphenols Communications 2010. (Montpellier, France 24-27 August). 1: 98-99
Abstract: A novel hydroxytyrosol-lipoic acid derivative has been synthesized. Key steps are an esterification reaction between tyrosol and -lipoic acid derivatives and a regioselective aromatic hydroxylation of the monohydroxylated ester performed by 2-iodoxybenzoic acid (IBX) followed by an in situ reduction with sodium dithionite (Na2S2O4). The novel ester exhibited an antiproliferative effect on the human colorectal adenocarcinoma HT-29 cell line significantly more potent than its parent compounds
URI: 978-2-7380-1282-1
http://hdl.handle.net/2067/1571
Appears in Collections:DABAC - Archivio della produzione scientifica

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