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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1561

Title: The thyroid disruptor 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT) prevents internalization of the TSH receptor
Authors: Picchietti, Simona
Belardinelli, Maria Cristina
Taddei, Anna Rita
Fausto, Anna Maria
Pellegrino, M.
Rossi, M.
Maggio, Roberto
Giorgi, Franco
Keywords: Thyroid-stimulating hormone receptor
Endocytosis
A2a receptor
1,1,1-Trichloro-2,2-bis(p-chlorophenyl) ethane
A2a receptor
Chinese hamster ovary cells
Issue Date: 2009
Publisher: Springer Verlag
Citation: Cervia, D. et al. 2009. The thyroid disruptor 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT) prevents internalization of the TSH receptor. "Cell and Tissue Research" 336(1): 31-40
Abstract: The thyroid-stimulating hormone (TSH) receptor (TSHr) was made specifically fluorescent by insertion of a tetracysteine motif (TSHr-FlAsH) into the C-terminal end and transiently transfected into COS-7 and HeLa cells. The observation that TSH administration caused the intracellular level of cAMP to increase in both TSHr-FlAsH-transfected cell types indicated that the FlAsH binding motif did not alter normal TSHr functioning. When transfected into HeLa cells and stimulated with TSH, the T
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Description: L'articolo è disponibile sul sito dell'editore http://www.springerlink.com/
DOI: 10.1007/s00441-008-0749-7
URI: http://hdl.handle.net/2067/1561
ISSN: 0302-766X
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