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|Title: ||Antiangiogenic role of somatostatin receptor 2 in a model of hypoxia-induced neovascularization in the retina: Results from transgenic mice|
|Authors: ||Dal Monte, Massimo|
|Issue Date: ||2007|
|Publisher: ||Association for Research in Vision and Ophthalmology (ARVO)|
|Citation: ||Dal Monte, M. et al. 2007. Antiangiogenic role of somatostatin receptor 2 in a model of hypoxia-induced neovascularization in the retina: Results from transgenic mice. "Investigative Ophthalmology and Visual Science" 48(8):3480-3489|
|Abstract: ||PURPOSE. To determine whether the somatostatin receptor 2 (sst2) influences angiogenesis and its associated factors in a model of hypoxia-induced retinal neovascularization.
METHODS. sst1-knockout (KO) mice, in which sst2 is overexpressed and overfunctional, and sst2-KO mice were used. Angiogenesis was evaluated in fluorescein-perfused retinas. Angiogenesis- associated factors were determined by RT-PCR and immunohistochemistry.
RESULTS. Retinal neovascularization was increased in sst2-KO mice,|
|Description: ||L'articolo è disponibile sul sito dell'editore http://www.arvo.org/eweb/StartPage.aspx?Site=arvo2|
|Appears in Collections:||DISA - Archivio della produzione scientifica|
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