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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1470

Title: Modulation of the neuronal response to ischemia by somatostatin analogues in wild-type and knock-out mouse retinas
Authors: Cervia, Davide
Martini, Davide
Ristori, Chiara
Catalani, Elisabetta
Timperio, Anna Maria
Bagnoli, Paola
Casini, Giovanni
Keywords: Cell death
G protein-coupled receptor kinases
Glutamate release
Regulators of G protein signalling
Somatostatin receptors
Issue Date: 2008
Publisher: Wiley-Blackwell
Citation: Cervia, D. et al. 2008. Modulation of the neuronal response to ischemia by somatostatin analogues in wild-type and knock-out mouse retinas. "Journal of Neurochemistry" 106(5): 2224-2235
Abstract: Somatostatin acts at five G protein-coupled receptors, sst1-sst5. In mouse ischemic retinas, the over-expression of sst2 (as in sst1 knock-out mice) results in reduction of cell death and glutamate release. Here, we reported that, in wild-type retinas, somatostatin, the multireceptor ligand pasireotide and the sst2 agonist octreotide decreased ischemia-induced cell death and that octreotide also decreased glutamate release. In contrast, cell death was increased by blocking sst2 with cyanamide. I
Description: L'articolo è disponibile sul sito dell'editore http://onlinelibrary.wiley.com/
DOI: 10.1111/j.1471-4159.2008.05556.x
URI: http://hdl.handle.net/2067/1470
ISSN: 0022-3042
Appears in Collections:DISA - Archivio della produzione scientifica

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