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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1463

Title: Molecular mechanisms of euplotin C-induced apoptosis: involvement of mitochondrial dysfunction, oxidative stress and proteases
Authors: Cervia, Davide
Garcia-Gil, Mercedes
Simonetti, Elisa
Di Giuseppe, Graziano
Guella, Graziano
Bagnoli, Paola
Dini, Fernando
Keywords: Tumour cells
Cell death
Bax/Bcl-2
Δψm
ROS
Calpains
Issue Date: 2007
Publisher: Springer Verlag
Citation: Cervia, D. et al. 2007. Molecular mechanisms of euplotin C-induced apoptosis: Involvement of mitochondrial dysfunction, oxidative stress and proteases. "Apoptosis" 12(8): 1349-1363
Abstract: The metabolite euplotin C (EC), isolated from the marine ciliate Euplotes crassus, is a powerful cytotoxic and pro-apoptotic agent in tumour cell lines. For instance, EC induces the rapid depletion of ryanodine Ca2+ stores, the release of cytochrome c from the mitochondria, and the activation of caspase-3, leading to apoptosis. The purpose of this study was to gain further insight into the mechanisms of EC-induced apoptosis in rat pheochromocytoma PC12 cells. We found that EC increases Bax/Bcl-2
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Description: L'articolo è disponibile sul sito dell'editore http://www.springerlink.com
DOI: 10.1007/s10495-007-0075-7
URI: http://hdl.handle.net/2067/1463
ISSN: 1360-8185
Appears in Collections:DISA - Archivio della produzione scientifica

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