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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1461

Title: Expression, pharmacology and functional role of somatostatin receptor subtypes 1 and 2 in human macrophages
Authors: Armani, Chiara
Catalani, Elisabetta
Balbarini, Alberto
Bagnoli, Paola
Cervia, Davide
Keywords: Neuropeptides
Monocytes
Trafficking
Cell viability
Chemokines
Metalloproteinases
Issue Date: 2007
Publisher: Society for Leukocyte Biology
Citation: Armani, C. et al. 2007. Expression, pharmacology and functional role of somatostatin receptor subtypes 1 and 2 in human macrophages. "Journal of Leukocyte Biology" 81(3): 845-855
Abstract: Somatostatin (SRIF)-14 is recognized as an important mediator between the nervous and the immune system, although the functional role of its receptors (sst1-sst5) is poorly understood in humans. In our study, we demonstrate that human macrophages differentiated from peripheral blood mononuclear cell-derived monocytes express both sst1 and sst2 mRNAs. Both sst1 and sst2 are mostly localized at the cell surface and display active binding sites. In particular, sst1/sst2 activation results in a weak
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Description: L'articolo è disponibile sul sito dell'editore http://leukocytebiology.org/default.aspx
DOI: 10.1189/jlb.0606417
URI: http://hdl.handle.net/2067/1461
ISSN: 0741-5400
Appears in Collections:DISA - Archivio della produzione scientifica

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