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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1459

Title: Cytotoxic effects and apoptotic signalling mechanisms of the sesquiterpenoid euplotin C, a secondary metabolite of the marine ciliate Euplotes crassus, in tumour cells
Authors: Cervia, Davide
Martini, Davide
Garcia-Gil, Mercedes
Di Giuseppe, Graziano
Guella, Graziano
Dini, Fernando
Bagnoli, Paola
Keywords: Ca2+ stores
Caspases
Cell death
Cytochrome c
Endoplasmic reticulum
Issue Date: 2006
Publisher: Springer Verlag
Citation: Cervia, D. et al. 2006. Cytotoxic effects and apoptotic signalling mechanisms of the sesquiterpenoid euplotin C, a secondary metabolite of the marine ciliate Euplotes crassus, in tumour cells. "Apoptosis" 11:829-843
Abstract: Most antitumour agents with cytotoxic properties induce apoptosis. The lipophilic compound euplotin C, isolated from the ciliate Euplotes crassus, is toxic to a number of different opportunistic or pathogenic microorganisms, although its mechanism of action is currently unknown. We report here that euplotin C is a powerful cytotoxic and pro-apoptotic agent in mouse AtT-20 and rat PC12 tumour-derived cell lines. In addition, we provide evidence that euplotin C treatment results in rapid activatio
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Description: L'articolo è disponibile sul sito dell'editore http://www.springerlink.com/
DOI: 10.1007/s10495-006-5700-3
URI: http://hdl.handle.net/2067/1459
ISSN: 1360-8185
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