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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1457

Title: Distinct functional properties of native somatostatin receptor subtype 5 compared with subtype 2 in the regulation of ACTH release by corticotroph tumor cells
Authors: Van der Hoek, Joost
Waaijers, Marlijn
Van Koetsveld, Peter M.
Sprij-Mooij, Diana
Feelders, Richard A.
Schmid, Herbert A.
Schoeffter, Philippe
Hoyer, Daniel
Cervia, Davide
Taylor, John E.
Culler, Michael D.
Lamberts, Steven W.J.
Hofland, Leo J.
Keywords: Cushing’s disease
Adrenocorticotropic hormone
Glucocorticoid
Issue Date: 2005
Publisher: American Physiological Society
Citation: Van der Hoek, J. et al. 2005. Distinct functional properties of native somatostatin receptor subtype 5 compared with subtype 2 in the regulation of ACTH release by corticotroph tumor cells. "American Journal of Physiology. Endocrinology and Metabolism" 289: E278–E287
Abstract: In a series of human corticotroph adenomas, we recently found predominant mRNA expression of somatostatin (SS) receptor subtype 5 (sst5). After 72 h, the multiligand SS analog SOM230, which has a very high sst5 binding affinity, but not Octreotide (OCT), significantly inhibited basal ACTH release. To further explore the role of sst5 in the regulation of ACTH release, we conducted additional studies with mouse AtT-20 cells. SOM230 showed a 7-fold higher ligand binding affinity and a 19-fold hig
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Description: L'articolo è disponibile sul sito dell'editore http://www.the-aps.org/index.htm
DOI: doi:10.1152/ajpendo.00004.2005
URI: http://hdl.handle.net/2067/1457
ISSN: 0193-1849
Appears in Collections:DISA - Archivio della produzione scientifica

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