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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1456

Title: Binding and functional properties of the novel somatostatin analogue KE 108 at native mouse somatostatin receptors
Authors: Cervia, Davide
Langenegger, Daniel
Schuepbach, Edi
Cammalleri, Maurizio
Schoeffter, Philippe
Schmid, Herbert A.
Bagnoli, Paola
Hoyer, Daniel
Keywords: Somatostatin agonists
AtT-20 cells
Mouse hippocampus
Receptor binding
cAMP
Ca2+ regulation
Epilepsy
Issue Date: 2005
Publisher: Elsevier
Citation: Cervia, D. et al. 2005. Binding and functional properties of the novel somatostatin analogue KE 108 at native mouse somatostatin receptors. "Neuropharmacology" 48(6): 881-893
Abstract: Clinically used somatostatin (SRIF) analogs octreotide and lanreotide act primarily by binding to SRIF receptor subtype 2 (sst2). In contrast, the recently described multiligand SOM230 binds with high affinity to sst1-3 and sst5 and KE 108 is characterised as a high affinity ligand for all five SRIF receptors. In tumoural mouse corticotrophs (AtT-20 cells) and in mouse hippocampus, binding and functional features of KE 108 were examined and compared to SRIF-14, octreotide and SOM230. In AtT-20
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Description: L'articolo è disponibile sul sito dell'editore http://www.sciencedirect.com/
DOI: 10.1016/j.neuropharm.2004.12.019
URI: http://hdl.handle.net/2067/1456
ISSN: 0028-3908
Appears in Collections:DISA - Archivio della produzione scientifica

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