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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1455

Title: Somatostatin receptors differentially affect spontaneous epileptiform activity in mouse hippocampal slices
Authors: Cammalleri, Maurizio
Cervia, Davide
Langenegger, Daniel
Liu, Yanqiang
Dal Monte, Massimo
Hoyer, Daniel
Bagnoli, Paola
Keywords: Epilepsy
Extracellular recording
Knockout mice
Somatostatin analogues
Issue Date: 2004
Publisher: Wiley-Blackwell
Citation: Cammalleri, M. et al. 2004. Somatostatin receptors differentially affect spontaneous epileptiform activity in mouse hippocampal slices. "European Journal of Neuroscience" 20(10): 2711-2721
Abstract: Somatostatin-14 (SRIF) reduces hippocampal epileptiform activity but the contribution of its specific receptors (sst1-5) is poorly understood. We have focused on sst1 and sst2 role in mediating SRIF modulation of epilepsy using hippocampal slices of wild type (WT) and sst1 or sst2 knock out (KO) mice. Recordings of epileptiform discharge induced by Mg2+-free medium with 4-aminopyridine were performed from the CA3 region before and after the application of SRIF compounds. In WT mice, SRIF and the
Description: L'articolo è disponibile sul sito dell'editore http://onlinelibrary.wiley.com/
DOI: 10.1111/j.1460-9568.2004.03741.x
URI: http://hdl.handle.net/2067/1455
ISSN: 0953-816X
Appears in Collections:DISA - Archivio della produzione scientifica

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