DSpace Unitus DSpace

Unitus DSpace >
Dipartimento di Scienze Ambientali >
DISA - Archivio della produzione scientifica >

Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1448

Title: Adenylyl cyclase/cAMP system involvement in the antiangiogenic effect of somatostatin in the retina. Results from transgenic mice.
Authors: Ristori, Chiara
Ferretti, Maria Enrica
Pavan, Barbara
Cervellati, Franco
Casini, Giovanni
Catalani, Elisabetta
Dal Monte, Massimo
Biondi, Carla
Keywords: Somatostatin
Mouse retina
Issue Date: 2008
Publisher: Springer Verlag
Citation: Ristori, C. et al. 2008. Adenylyl cyclase/cAMP system involvement in the antiangiogenic effect of somatostatin in the retina. Results from transgenic mice. "Neurochemical Research" 33 (7): 1247-1255
Abstract: Neoangiogenesis is a response to retinal hypoxia that is inhibited by somatostatin (SRIF) through its subtype 2 receptor (sst2). Using a mouse model of hypoxia-induced retinopathy, we investigated the possibility that inhibition of adenylyl cyclase (AC) is involved in SRIF anti-angiogenic actions. Hypoxia increased AC responsiveness in wild type (WT) retinas and in retinas lacking sst2, but not in sst2-overexpressing retinas. Hypoxia also altered AC isoform expression, but with different pattern
...more
Description: L'articolo è disponibile sul sito dell'editore http://www.springerlink.com/
DOI: 10.1007/s11064-007-9576-6
URI: http://hdl.handle.net/2067/1448
ISSN: 0364-3190
Appears in Collections:DISA - Archivio della produzione scientifica

Files in This Item:

File Description SizeFormat
Ristori et al 2008.pdf459.68 kBAdobe PDFView/Open


This item is protected by original copyright

Recommend this item

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! Unitus DSpace  © 2005 Università degli Studi della Tuscia - Feedback Supporto, sviluppo e manutenzione ICT a cura del CASPUR