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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1446

Title: Native somatostatin sst2 and sst5 receptors functionally coupled to Gi/o-protein, but not to the serum response element in AtT-20 mouse tumour corticotrophs
Authors: Cervia, Davide
Fehlmann, Dominique
Hoyer, Daniel
Keywords: Somatostatin analogues
Receptor autoradiography
[35S]GTPγS binding
Serum response element (SRE)
Luciferase assay
AtT-20 cells
Issue Date: 2003
Publisher: Springer Verlag
Citation: Cervia, D., Fehlmann, D., Hoyer, D. 2003. Native somatostatin sst2 and sst5 receptors functionally coupled to Gi/o-protein, but not to the serum response element in AtT-20 mouse tumour corticotrophs. "Naunyn-Schmiedeberg's Archives of Pharmacology" 367(6): 578-587
Abstract: Of the five cloned somatostatin (SRIF: somatotropin release inhibitory factor) receptors (sst1-5), only sst2 and sst5 receptors appear to be endogenously expressed and functionally active in AtT-20 mouse anterior pituitary tumour cells. In this study, the presence and the functional coupling of SRIF receptors to G-protein in AtT-20 cells was evaluated by receptor autoradiography and guanosine-5′-O-(3-[35S]thio)-triphosphate ([35S]GTPγS) binding, respectively. In addition, transcriptional effects
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Description: L'articolo è disponibile sul sito dell'editore http://www.springerlink.com/
DOI: 10.1007/s00210-003-0752-1
URI: http://hdl.handle.net/2067/1446
ISSN: 0028-1298
Appears in Collections:DISA - Archivio della produzione scientifica

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