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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1444

Title: Pharmacological characterisation of native somatostatin receptors in AtT-20 mouse tumour corticotrophs
Authors: Cervia, Davide
Nunn, Caroline
Fehlmann, Dominique
Langenegger, Daniel
Schuepbach, Edi
Hoyer, Daniel
Keywords: Somatostatin
Somatostatin receptor agonists
Somatostatin receptor antagonists
AtT-20 mouse tumour corticotrophs
Radioligand binding
cAMP measurements
Issue Date: 2003
Publisher: Wiley-Blackwell
Citation: Cervia, D. et al. 2003. Pharmacological characterisation of native somatostatin receptors in AtT-20 mouse tumour corticotrophs. "British Journal of Pharmacology" 139(1): 109-121
Abstract: 1. The mouse corticotroph tumour cell line AtT-20, is a useful model to investigate the physiological role of native somatostatin (SRIF) receptor subtypes (sst1-sst5). The objective of this study was to characterise the pharmacological features and the functional effects of SRIF receptors expressed by AtT-20 cells using radioligand binding and cAMP accumulation. 2. [125I]LTT-SRIF-28, [125I]CGP 23996, [125I]Tyr10-cortistatin-14 and [125I]Tyr3-octreotide labelled SRIF receptor binding sites with
Description: L'articolo è disponibile sul sito dell'editore http://onlinelibrary.wiley.com/
DOI: 10.1038/sj.bjp.0705235
URI: http://hdl.handle.net/2067/1444
ISSN: 0007-1188
Appears in Collections:DISA - Archivio della produzione scientifica

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