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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1443

Title: Biological activity of somatostatin receptors in GC rat tumour somatotrophs: evidence with sst1-sst5 receptor-selective nonpeptidyl agonists
Authors: Cervia, Davide
Zizzari, P.
Pavan, Barbara
Schuepbach, Edi
Langenegger, Daniel
Hoyer, Daniel
Biondi, Carla
Epelbaum, Jacques
Bagnoli, Paola
Keywords: SRIF receptor agonists
Radioligand binding
Intracellular Ca2+
Spectral analysis
Adenosine 3'
5'-cyclic monophosphate
Growth hormone
GC cell culture
Issue Date: 2003
Publisher: Elsevier
Citation: Cervia, D. et al. 2003. Biological activity of somatostatin receptors in GC rat tumour somatotrophs: evidence with sst1-sst5 receptor-selective nonpeptidyl agonists. "Neuropharmacology" 44(5): 672-685
Abstract: The physiological actions of somatostatin-14 (SRIF) receptor subtypes (sst1-sst5), which are endogenously expressed in GC cells, have not yet been elucidated, although there is evidence that sst2 receptors are negatively coupled to cytosolic free Ca2+ concentration ([Ca2+]i) and cAMP accumulation. In addition, both sst1 and sst2 receptors are negatively coupled to growth hormone (GH) secretion in GC cells. Here we report on studies concerning the expression, the pharmacology and the functional r
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Description: L'articolo è disponibile sul sito dell'editore http://www.sciencedirect.com/
DOI: 10.1016/S0028-3908(03)00031-5
URI: http://hdl.handle.net/2067/1443
ISSN: 0028-3908
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