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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1441

Title: Inhibitory control of growth hormone secretion by somatostatin in rat pituitary GC cells: sst2 but not sst1 receptors are coupled to an inhibition of single-cell intracellular free calcium concentrations
Authors: Cervia, Davide
Petrucci, Cristina
Bluet-Pajot, Marie Thérèse
Epelbaum, Jacques
Bagnoli, Paola
Keywords: GC cell line
Growth hormone
Somatostatin
Somatostatin antagonists
Somatostatin receptors
Somatotropes
Issue Date: 2002
Publisher: Karger
Citation: Cervia, D. et al. 2002. Inhibitory control of growth hormone secretion by somatostatin in rat pituitary GC cells: sst2 but not sst1 receptors are coupled to an inhibition of single-cell intracellular free calcium concentrations. "Neuroendocrinology" 76(2):99-110
Abstract: Rat pituitary tumor cells (GC cells) exhibit spontaneous oscillations of intracellular free calcium concentration ([Ca2+]i) that allow a continuous release of growth hormone (GH). Of the SRIH receptor subtypes (sst receptors) mediating SRIH action, sst1 and sst2 receptors are highly expressed by GC cell membranes. In the present study, the effects of sst1 or sst2 receptor activation on single-cell [Ca2+]i were investigated in GC cells by confocal fluorescence microscopy. In addition, the effects
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Description: L'articolo è disponibile sul sito dell'editore http://www.karger.com
DOI: 10.1159/000064424
URI: http://hdl.handle.net/2067/1441
ISSN: 0028-3835
Appears in Collections:DISA - Archivio della produzione scientifica

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