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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1432

Title: Somatostatin (SRIF) modulates distinct signaling pathways in rat pituitary tumor cells. Negative coupling of SRIF receptor subtypes 1 and 2 to arachidonic acid release
Authors: Cervia, Davide
Fiorini, Sara
Pavan, Barbara
Biondi, Carla
Bagnoli, Paola
Keywords: Peptide receptors
Agonists
Antagonist
Intracellular Ca2+
cAMP
PLA2/AA
Cell culture
Fluorimetry
Biochemical dosages
Somatostatin
Issue Date: 2002
Publisher: Springer Verlag
Citation: Cervia, D. et al. 2002. Somatostatin (SRIF) modulates distinct signaling pathways in rat pituitary tumor cells; negative coupling of SRIF receptor subtypes 1 and 2 to arachidonic acid release. "Naunyn-Schmiedeberg's Archives of Pharmacology" 365(3):200-209
Abstract: The somatotropin release inhibiting factor somatostatin-14 (SRIF) is known to activate distinct receptor subtypes (sst1-5). In rat pituitary tumor cells (GC cells), sst2 but not sst1 receptors mediate the SRIF-induced inhibition of intracellular concentration of Ca2+ ([Ca2+]i) and are negatively coupled to cAMP-dependent pathways. In the present study, transduction mechanisms coupling distinct SRIF receptors to their specific functional role were investigated with the use of both SRIF agonists w
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Description: L'articolo è disponibile sul sito dell'editore http://www.springerlink.com/
DOI: 10.1007/s00210-001-0509-7
URI: http://hdl.handle.net/2067/1432
ISSN: 0028-1298
Appears in Collections:DISA - Archivio della produzione scientifica

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