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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1430

Title: Somatostatin-induced control of cytosolic free calcium in pituitary tumour cells
Authors: Petrucci, Cristina
Cervia, Davide
Buzzi, Marco
Biondi, Carla
Bagnoli, Paola
Keywords: Sst2 receptor
Agonists
Antagonist
Intracellular Ca2+
Cyclic AMP-dependent pathways
Cell culture
Fluorimetry
Confocal immunofluorescence
Issue Date: 2000
Publisher: Nature Publishing Group
Citation: Petrucci, C. et al. 2000. Somatostatin-induced control of cytosolic free calcium in pituitary tumour cells. "British Journal of Pharmacology" 129(3): 471-484
Abstract: 1 In rat pituitary tumor cells (GC cells), spontaneous oscillations of the intracellular concentration of Ca2+ ([Ca2+]i) induce growth hormone (GH) secretion that is inhibited by octreotide, a somatostatin (SRIF) agonist which binds to SRIF subtype (sst) receptor 2. The effects of its functional activation on the control of [Ca2+]i were investigated using fluorimetric measurements of [Ca2+]i. 2 SRIF decreases the basal [Ca2+]i and the [Ca2+]i rise in response to forskolin (FSK) through the inhi
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Description: L'articolo è disponibile sul sito del nuovo editore http://onlinelibrary.wiley.com/
DOI: 10.1038/sj.bjp.0703075
URI: http://hdl.handle.net/2067/1430
ISSN: 0007-1188
Appears in Collections:DISA - Archivio della produzione scientifica

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