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|Title: ||Expression, localization and functional coupling of the somatostatin receptor subtype 2 in a mouse model of oxygen-induced retinopathy|
|Authors: ||Dal Monte, Massimo|
|Issue Date: ||2010|
|Publisher: ||Association for Research in Vision and Ophthalmology (ARVO)|
|Citation: ||Dal Monte, M. et al. 2010. Expression, localization, and functional coupling of the somatostatin receptor subtype 2 in a mouse model of oxygen-induced retinopathy. "Investigative Ophthalmology and Visual Science" 51(4): 1848-1856|
|Abstract: ||PURPOSE. In the mouse model of oxygen-induced retinopathy (OIR) somatostatin (SRIF) acting at the SRIF receptor subtype 2 (sst2) inhibits angiogenic responses to hypoxia through a downregulation of vascular endothelial growth factor. Information on the sites where SRIF-sst2 interactions take place is lacking, and downstream effectors mediating SRIF-sst2 antiangiogenic actions are unknown.
METHODS. In the OIR model, retinal expression of SRIF was evaluated with RT-PCR and RIA. The bindings of [1|
|Description: ||L'articolo è disponibile sul sito dell'editore http://www.arvo.org/eweb/StartPage.aspx?Site=arvo2|
|Appears in Collections:||DISA - Archivio della produzione scientifica|
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