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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1429

Title: Expression, localization and functional coupling of the somatostatin receptor subtype 2 in a mouse model of oxygen-induced retinopathy
Authors: Dal Monte, Massimo
Ristori, Chiara
Videau, Catherine
Loudes, Catherine
Martini, Davide
Casini, Giovanni
Epelbaum, Jacques
Bagnoli, Paola
Keywords: Angiogenesis
Hypoxia
Somatostatinergic system
Retinal vasculature
Issue Date: 2010
Publisher: Association for Research in Vision and Ophthalmology (ARVO)
Citation: Dal Monte, M. et al. 2010. Expression, localization, and functional coupling of the somatostatin receptor subtype 2 in a mouse model of oxygen-induced retinopathy. "Investigative Ophthalmology and Visual Science" 51(4): 1848-1856
Abstract: PURPOSE. In the mouse model of oxygen-induced retinopathy (OIR) somatostatin (SRIF) acting at the SRIF receptor subtype 2 (sst2) inhibits angiogenic responses to hypoxia through a downregulation of vascular endothelial growth factor. Information on the sites where SRIF-sst2 interactions take place is lacking, and downstream effectors mediating SRIF-sst2 antiangiogenic actions are unknown. METHODS. In the OIR model, retinal expression of SRIF was evaluated with RT-PCR and RIA. The bindings of [1
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Description: L'articolo è disponibile sul sito dell'editore http://www.arvo.org/eweb/StartPage.aspx?Site=arvo2
DOI: 10.1167/iovs.09-4472
URI: http://hdl.handle.net/2067/1429
ISSN: 0146-0404
Appears in Collections:DISA - Archivio della produzione scientifica

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