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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1347

Title: A selective de-O-methylation of guaiacyl lignans to corresponding catechol derivatives by 2-iodoxybenzoic acid (IBX). The role of the catechol moiety on the toxicity of lignans
Authors: Bernini, Roberta
Barontini, Maurizio
Mosesso, Pasquale
Pepe, Gaetano
Willfoer, Stefan M.
Sjoeholm, Rainer E.
Eklund, Patrick C.
Saladino, Raffaele
Keywords: IBX
IBX
Issue Date: 2009
Publisher: RSC Publishing
Citation: Bernini, R. et al. 2009. A selective de-O-methylation of guaiacyl lignans to corresponding catechol derivatives by 2-iodoxybenzoic acid (IBX). The role of the catechol moiety on the toxicity of lignans. "Organic & Biomolecular Chemistry" 7(11): 2367-2377
Abstract: We report here the first selective de-O-methylation of a large panel of guaiacyl lignans to the corresponding catechol derivatives by using IBX as primary oxidant under green conditions (dimethyl carbonate–H2O solvent) through an in situ reduction procedure. The influence of the catechol moiety on the cytotoxicity and genotoxicity of new lignan derivatives has been investigated. The results obtained indicated that the presence of the catechol moiety sharply enhances the clastogenic potential
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Description: L'articolo è disponibile sul sito dell'editore: http://www.rsc.org
DOI: 10.1039/b822661j
URI: http://hdl.handle.net/2067/1347
ISSN: 1477-0520
Appears in Collections:DABAC - Archivio della produzione scientifica

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