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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1344

Title: Ochratoxin A causes DNA damage and cytogenetic effects but no DNA adducts in rats
Authors: Mally, Angela
Pepe, Gaetano
Ravoori, Srivani
Fiore, Mario
Gupta, Ramesh C.
Dekant, Wolfgang
Mosesso, Pasquale
Issue Date: 2005
Publisher: American Chemical Society
Citation: Mally, A. et al. 2005. Ochratoxin A causes DNA damage and cytogenetic effects but no DNA adducts in rats. "Chem. Res. Toxicol." 18: 1253-1261
Abstract: Ochratoxin A (OTA) is a potent nephrotoxin and renal carcinogen in rats, but the mechanism of OTA tumorigenicity is unknown. Ochratoxin A has been shown to be negative in many genetic toxicology test in vitro. However, the potential of OTA to induce genotoxic effects has not been investigated in male rats, the most sensitive species for OTA-induced tumor formation. In this study, male F344 rats were repeatedly administered OTA (0, 250, 500, 1000, and 2000 íg/kg of body wt) or the non-chlori
Description: L'articolo è disponibile sul sito dell'editore: http://www.pubs.acs.org
DOI: 10.1021/tx049650x
URI: http://hdl.handle.net/2067/1344
ISSN: 0893-228X
Appears in Collections:DABAC - Archivio della produzione scientifica

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