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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1341

Title: Methyltrioxorhenium catalysed synthesis of highly oxidised aryltetralin lignans with anti-topoisomerase II and apoptogenic activities
Authors: Fiani, Cinzia
Belfiore, Maria Cristina
Gualandi, Giampiero
Penna, Sabrina
Mosesso, Pasquale
Issue Date: 2005
Publisher: Elsevier
Citation: Saladino, R. et al. 2005. Methyltrioxorhenium catalysed synthesis of highly oxidised aryltetralin lignans with anti-topoisomerase II and apoptogenic activities. "Bioorganic & Medicinal Chemistry" 13: 5949–5960
Abstract: A novel and efficient procedure to prepare highly oxidised aryltetralin lignans, such as isopodophyllotoxone and (-)-aristologone derivatives, by oxidation of podophyllotoxin and galbulin with methylrhenium trioxide (MTO) and novel MTO heterogeneous catalysts is reported. It is noteworthy that in the case of isopodophyllotoxone derivatives the functionalisation of the C-4 position of the C-ring and the ring-opening of the D-lactone moiety increased the activity against topoisomerase II while
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Description: L'articolo è disponibile sul sito dell'editore: http://www.sciencedirect.com
DOI: 10.1016/j.bmc.2005.07.017
URI: http://hdl.handle.net/2067/1341
ISSN: 0968-0896
Appears in Collections:DABAC - Archivio della produzione scientifica

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