http://http://dspace.unitus.it:80 The DSpace digital repository system captures, stores, indexes, preserves, and distributes digital research material. 2013-06-18T04:01:08Z http://hdl.handle.net/2067/1475 Title: Mapping of the full length and the truncated interleukin-18 receptor alpha transcripts in the mouse brain Authors: Alboni, Silvia; Cervia, Davide; Ross, Brendon; Montanari, Claudia; Sanchez-Gonzales, Alejandro; Sanchez-Alavez, Manuel; Garibaldi-Marcondes, Maria Cecilia; De Vries, David; Sugama, Shuei; Brunello, Nicoletta; Blom, Joan; Tascedda, Fabio; Conti, Bruno Abstract: The cytokine IL-18 acts on the CNS both in physiological and pathological conditions. Its action occurs through the heterodimeric receptor IL-18Rα\β. To better understand IL-18 central effects, we investigated in the mouse brain the distribution of two IL-18Rα transcripts, a full length and an isoform lacking the intracellular domain hypothesized to be a decoy receptor. Both isoforms were expressed in neurons throughout the brain primarily with overlapping distribution but also with some unique pattern. These data suggest that IL-18 may modulate neuronal functions and that its action may be regulated through expression of a decoy receptor. Description: L'articolo è disponibile sul sito dell'editore http://www.sciencedirect.com/ 2008-12-31T23:00:00Z